Duke vs Clemson 2025: Stat Line Predictions for Key Blue Devils Players
By Md Zamal Uddin | November 1, 2025 | Sports Desk
Week 10 of the 2025 college football season brings a high-stakes showdown between two ACC powerhouses — the Duke Blue Devils and the Clemson Tigers. As Duke heads to Memorial Stadium in Clemson, South Carolina, both teams are hungry for redemption and a statement win.
For Duke, this matchup is a make-or-break game that could define the direction of their season. Meanwhile, Clemson — one of the most disappointing programs in 2025 — is desperate to get back on track after a string of inconsistent performances.
According to FanDuel Sportsbook, the over/under for the game is set at 54.5 points, suggesting an offensive battle is on the horizon. Here’s a look at how some of Duke’s biggest stars are projected to perform against an underrated but physical Clemson defense.
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Darian Mensah, Quarterback
Predicted Stat Line: 24-of-32 passing, 275 yards, 2 touchdowns, 0 interceptions
Sophomore quarterback Darian Mensah has been the definition of consistency for the Duke Blue Devils this season. The former Tulane transfer has completed over 70% of his passes in 2025 and has shown poise in every type of defensive look.
Mensah’s only rough outing came in Week 3 against his former team, Tulane. Since then, he’s been laser-sharp, completing at least 67% of his throws in every contest. His precision and pocket awareness have made him one of the top emerging quarterbacks in the ACC.
However, Clemson’s secondary will test his decision-making. The Tigers’ defense, which ranks 58th nationally in coverage according to PFF (Pro Football Focus), thrives in man coverage schemes. Their corners are aggressive, and their safeties close down throwing lanes quickly.
Still, Mensah’s composure and quick release give him an edge. Expect the 6'3", 205-pound signal caller to move the chains efficiently, using short-to-intermediate routes to counter Clemson’s pressure. If he stays clean in the pocket, he could easily surpass 275 yards passing.
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Cooper Barkate, Wide Receiver
Predicted Stat Line: 10 targets, 7 receptions, 81 yards, 1 touchdown
Wideout Cooper Barkate has emerged as the go-to receiver in Duke’s passing attack. Against Georgia Tech, he delivered a career-best performance — 13 catches for 172 yards — solidifying himself as one of the most dependable receivers in the ACC.
While replicating those numbers against Clemson’s man-heavy coverage will be tough, Barkate’s sharp route-running and hands make him a tough matchup for any cornerback. Expect Duke’s quarterback to look his way early and often, particularly on third downs and in red zone situations.
Clemson’s defense, led by an athletic secondary, often brackets top receivers with double coverage. But Barkate’s ability to find soft spots and his chemistry with Mensah should still allow him to post strong numbers.Clemson Tigers football, Duke football predictions
If the Blue Devils fall behind, Barkate could see even more volume — potentially pushing him toward the 100-yard mark once again. His balance of speed, awareness, and body control makes him a vital weapon in Duke’s offensive game plan.
Nate Sheppard, Running Back
Predicted Stat Line: 16 carries, 70 yards, 1 touchdown
The Duke vs Clemson 2025 matchup could be won or lost in the trenches — specifically between Duke’s offensive line and Clemson’s ferocious defensive front. Running back Nate Sheppard will play a critical role in balancing the offense.
Clemson’s defensive line, featuring Peter Woods and T.J. Parker, is among the most talented in the nation and is loaded with future NFL Draft talent. For Sheppard, patience and vision will be key to finding lanes against this dominant unit.
Expect Duke to establish the run early to keep Clemson’s linebackers honest. If Sheppard can churn out 4–5 yards per carry, it will open up play-action opportunities for Mensah to exploit downfield.
Even if the raw numbers don’t jump off the stat sheet, Sheppard’s contribution in short-yardage and goal-line situations could be the difference-maker for Duke’s offense. A touchdown on the ground would cap off a strong performance from the junior running back.Duke vs Clemson 2025, Duke Blue Devils football
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Final Thoughts: Duke vs Clemson Game Outlook
This ACC Week 10 showdown has all the ingredients for a classic. The Duke Blue Devils offense, led by Mensah, Barkate, and Sheppard, will look to attack Clemson’s aggressive defense with quick reads and balanced play-calling.
Clemson, despite its struggles this year, remains one of the toughest teams to beat at home. If Duke’s offensive line can neutralize the Tigers’ front seven, the Blue Devils have a real shot at pulling off an upset on the road.
With both teams fighting for bowl positioning and pride, expect a high-intensity matchup where every play counts.
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